硫氮(艹卓)酮对心肌钙反常损伤的影响

THE EFFECT OF DILTIAZEM ON THE CALCIUM PARADOX—RELATEDMYOCARDIAL INJURY

本实验建立心肌钙反常损伤模型,观察钙通道阻滞剂硫氮(艹卓)酮对心肌钙反常损伤的影响。发现硫氮(艹卓)酮能显著减轻心肌挛缩,提高冠脉流量和冠脉流出液中超氧化物歧化酶(SOD)活性,降低心肌细胞内的 CPK 释放及心室肌组织钙含量。实验结果表明,硫氮(艹卓)酮对心肌钙反常损伤有明显的保护作用。

Experiments were undertaken to determine whether the diltiazem,a slow-channel calcium -antagonist,protects calcium-deprived rat heart muscle against the consequences of readmit- ting calcium.Dilitiazem significantly lightened myocardial contraeture,increased coronary flow and SOD activity in coronary efflux and markedly reduced a release of CPK and total calcium con- tents of ventricular muscle tissue after reperfusion with normal calcium-containing medium. These results indicat that diltiazem has a protective effect on the calcium paradox-related my- ocardial injury.