口服避孕药对动脉血压与血浆心钠素水平的影响

EFFECT OF ORAL CONTRACEPTIVES ON ARTERIAL BLOOD PRESSURE AND PLASMA ANP LEVELS IN WOMEN

观察25例口服避孕药妇女的血压和血浆 ANP 变化,其中血压正常者血浆ANP 无明显变化(P>0.05),血压增高者血浆 ANP 明显增高(P<0.01)。服药者血浆ANP 水平与血压呈高度正相关(P<0.01),与服药时间无关(P>0.05)。提示口服避孕药可能是通过血压增高使血浆 ANP 水平增加,而其引起的血压增高是高 ANP 型的。

The plasma levels of atrial natriuretic peptides(ANP)and the blood pressure in 25 subjects using oral contraceptives were observed.The levels of ANP in subjects with elevated blood pres- sure were higher than those with normal blood pressure(P<0.01).The ANP levels were posi- tively and significantly correlated with blood pressure(P<0.01).The results indicated that oral contraceptives increased the levels of ANP by increasing blood pressure and this hypertension is of“the high ANP”type.