糖尿病铁代谢异常及其临床意义

Abnormality of Iron Metabolism in Diabetes Mellitus and Its Clinical Significance

对27例控制不良的糖尿病人(DM)及10例正常对照者测定血清铁(SI)、铁蛋白(SF)及总铁结合力(TIBC)测定。27例DM分为A、B两组,A组病程长、有慢性并发症;B组病程短、无慢性并发症。结果表明:27例DM之SF均明显高于正常对照组,而DMA组SF又明显高于DMB组(P<0.05)。DM组与正常对照组之间SI、TIBC值无明显差异。本组资料提示DM尤其是伴慢性并发症者有SF升高,表明体内铁贮存过多,此可降低葡萄糖的外周利用并损伤胰岛β细胞,故铁贮存过量可能是DM及慢性并发症发生与发展的因素之一。

The levels of serum iron(SI),serum ferritin(SF)and total iron bind capacity (TIBC)were determined in 27 uncontrolled NIDDM and 10 normal control subjects.27 NIDDM were divided into group A(with chronic diabetic complications)and group B(without complications).The results suggested that in all 27 NIDDM,the SF was significantly higher than that of the normal con- trols.In group A,the SF was higher than that of the group B.No significant differences in SI,and TIBC were found between DM and normal controls.Results of this study strongly substantiated that uncontrolled diabetics,especially with chronic diabetic complications,had an excess of iron storage as manifested by elevated SF.Excessive iron storage in tissues can decrease the peripheral glucose utiliza- tion and injure the β-cells,so excessive iron storage may be a cause of DM and its chronic complica- tions.A reduction of elevated SF may be a good omen for the control of DM.