钙及cAMP在消炎痛引起的急性胃粘膜损害中的作用

The Role of Calcium and cAMP in Acute Gastric Mucosal Lesions Induced by Indomethacin

用消炎痛(30mg/kg)致急性胃粘膜损害观察胃粘膜钙及胃组织cAMP含量的变化以及异搏定对消炎痛引起的胃粘膜钙及胃组织cAMP含量变化的影响。结果表明:大鼠给予消炎痛后,随着时间延长,胃粘膜损害密度逐步增加.同时胃粘膜钙含量和胃组织cAMP含量逐步降低。预先给予异搏定(5mg/kg,10mg/kg)可使消失痛引起的急性胃粘膜损害明显减轻,同时,胃粘膜钙及胃组织cAMP含量不再下降,cAMP反而有所升高。

The changes of gastric tissue contents of calcium and cAMP, and the ef- fects of verapamil on these changes were studied in rats with acute gastric mucosal lesions in- duced by indomethacin (30mg/kg). The results showed that: (1)after administration of in- domethacin, the gastric lesion index gradually increased, accompanied by a progressive re- duction of the contents of gastric tissue calcium and cAMP; (2)pre-treatment with verapmil alleviated the acute gastric mucosal lesions induced by indomethacin and prevented the reduc- tion of gastric tissue calcium and cAMP, suggesting the gastric tissue calcium and cAMP might play a role in the production of gastric mucosal lesions induced by indomethacin.