急性复发期多发性硬化患者外周血淋巴细胞产生白细胞介素2的研究

Study on IL-2 Activity in Patients with Acute Relapsing Multiple Sclerosis

应用改良ＭＴＴ比色分析法，测定５例急性复发期多发性硬化（ＭＳ）患者外周组淋巴细胞在ＰＨＡ刺激下产生的白细胞介素２（ＩＬ－２）活性。结果表明，急性复发期ＭＳ患者外周血淋巴细胞在ＰＨＡ刺激下产生的ＩＬ－２活性明显低于健康对照者，提示急性复发期ＭＳ细胞免疫功能受损。

In this paper, a modified 3-(4,5-Dimethylthiazol -2-yl )-2,5-diphenyltetrazolium bromide (MTT)colorimetric assay was used to measure the IL-2 activity produced by peripheral blood lymphocytes stimulated with PHA in vitro in 5 patients with acute relapsing multiple sclerosis. The result showed that the IL-2 activity was significantly lower in the multiple sclerosis patients in acute relapse than in the healthy volunteers and also indicated that the function of cell mediated immunity was impaired in the acute relapse multiple sclerosis.