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水飞蓟素在水中溶解度的测定及关联 被引量:10

The measurement and correlation of solubilities of silymarin in water
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摘要 通过自制的固-液平衡装置测定了从293.15K到313.15K温度下水飞蓟素在水中的溶解度.实验数据用理想溶液模型及经验方程进行了关联.其中经验方程1误差最小,经验方程2和理想溶液模型关联也得到了较满意的结果. Solubilities of silymarin in water were measured by using a solid-liquid equilibrium cell at temperature from 293.15 to 313.15K. The ideal solution model and two empirical equations were applied to correlate the solid-liquid equilibrium data. The error with the first empirical equation is the least among the three correlated methods, the ideal solution model and the second empirical equation can correlated the solubility data well.
出处 《苏州大学学报(自然科学版)》 CAS 2004年第2期79-83,共5页 Journal of Soochow University(Natural Science Edition)
关键词 水飞蓟素 关联 自制 溶解度 测定 溶液 误差 经验方程 理想 实验数据 solid-liquid equilibrium solubility silymarin empirical equations
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  • 1KAI T,AKIYAMA Y,NOMURA S,et al.Oral absorption improvement of poorly soluble drug using solid dispersion techniques[J].Chem Pharm Bull,1996,44(3): 568-571.
  • 2APELBLAT A.MANZUROLA E.Solubilities of o-acetylaslicylic,3,5-dinitrosalicyclic,and p-toluic acid,and magnesium-DL-aspartate in water from 278K to 348K[J].J Chem Thermodyn,1999,31:85-91.

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