胃粘膜肠上皮化生与胃癌组织学发生之关系

INTESTINAL METAPLASIA OF GASTRIC MUCOSA AND RALATION TO HISTOLOGICAL GENERATION OF GASTRIC CARCINOMA

未经选择的良恶性手术胃标本166例,其中胃癌83例,良性病变83例:用瑞士席卷法取材,切片后用组织化学进行研究,采用AB(pH2.5)—PAS,PB—KOH—PAS,AB(pH1.0)—PAS方法把肠化生分为小肠型化生和结肠型化生。再用HID—AB(pH2.5)方法把结肠型化生分为含硫酸粘液的S结肠型化生和含O乙酰唾液酸粘液的O结肠型化生。小肠型化生只分泌中性粘液和N乙酰唾液酸粘液,它多见于良性病变,而S结肠型化生在胃癌中显著高于良性病变,提示它和胃癌前期病变有关。

One hundred and sixty-six unchoosed benign and malignant surgical specimens of stomach were taken by Swiss'-engulfing way and studied by histochemistry, According to the stainings of alcian blue pH 2.5/periodic acid-schiff (AB pH 2.5/PAs), periodic acid-borohydride/kalium hydroxide/PAs (PB/KOH/PAS) and alcian bllcian blue pH 1.0/periodic acid-schiff (AB pH 1.0/PAS) procedures intestinal metaplasia (IM) was classified into small intestinal type (ST) and Colonic type (CT). The latter can also be classified into sulphomucin colonic type (SCT) and O-acetyl sialomucin colonic type (OCT) through highiron diamine/alcian blue pH 2.5 (HID/AB pH2.5)technique, ST IM produced only neutral mucin and N-acetylsialomucin was usually in benign lesions; honever, SCT IM was much higher in gastric carcinomas than in benign lesions (P<0.05), This suggests that SCT IM may be correlated with gastric precancerous lesions.