健康献血员及肝病患者中丙型肝炎病毒抗体的阳性率

INCIDENCE OF ANTIBODY TO HEPATITIS C VIRUS IN HEALTHY BLOOD DONORS AND PATIENTS WITH LIVER DISEASE

本文对长江入海口北部南通地区不同人群中丙型肝炎病毒抗体(C100-3 Ab)进行了调查。C100-3 Ab阳性率,献血员为0.67%(3/451),非肝病患者为1.3%(1/78)、急性肝炎、慢性肝炎及肝硬变患者分别为0%(0/89),2.7%(5/186)和4.5%(2/44),在16例肝癌中检出1例阳性(6.3%).8例C100-3 Ab阳性慢性肝病中4例(50%)有输血史,与乙肝病毒(HBV)重叠感染5例(62.5%).在急性肝炎中甲肝抗体(HAV-IgM Ab)阳性高达61.8%(55/89).慢性肝病中HBV感染在90%以上.提示HBV感染仍是该地区慢性肝病的主要病因.

The incidence of antibody to hepatitis C virus (C100-3 Ab) was investigated; blood donors, patients with or without liver disease in the inshore Nantong area of the Y ingtze River. The incidence of C100-3 Ab in the different population was 0% (0/89) in acute hepatitis, 2.7%(5/186) in chronic hepatitis, 4.5% (2/44) in liver cirrhosis, 6.3% (1/16) in primary hepatocellular carcinoma, 1.3%(1/78) in patients without hepatic disease, and 0.67% (3/451) in blood donors. Among 8 C100-3 Ab positive-patients with chronic liver disease, 4 of 8(50%) cases had history of blood transfusion, 5 of 8 (62.5%) patients were infected by hepatitis B Virus (HB) and HCV. On the other hand, the incidence of antibody to hepatitis Av irus (HAV-IgM) was 61%(55/89) in patients with acute hepatitis, 90% of cases were infected by HBV in patients with chronic liver disease. These data suggest that HCV infection is not an important etiological factor for liver disease and HBV is still the most important causative agent of chronic liver disease in Nantong area.