门冬氨酸洛美沙星抗菌作用研究

STUDIES OF ANTIBACTERIAL ACTIVITY OF LOMEFLOXACIN ASPARTATE IN VIVO AND IN VITRO

本文对国内研制的喹诺酮类抗菌药新品种门冬氨酸洛美沙星进行体内、外抗菌作用研究,并与同类药物氟哌酸、环丙沙星、氟嗪酸进行比较。结果提示:门冬氨酸洛美沙星对小鼠细菌感染具有明显的保护效果,其中对绿脓杆菌和金葡菌感染,其抗菌活性强于氟哌酸而弱于环丙沙星;对大肠杆菌,其活性与氟哌酸相近。体外试验提示:它对本文所测22属314株细菌的最小抑菌浓度均在0.063～16μg/ml之间。91.4%被检菌的最小抑菌浓度在2μg/ml以下(包括2μg/ml),说明其为一广谱、高效的抗生素。

The antibacterial activity in vivo and in vitro of lomefloxacin aspartate was observed and compared with those of norfloxacin, ciprofloxacin, and ofloxacin. Lomefloxacin aspartate has good protective effect on mice infected by lethal bacteria. To mice infected by Pseudomonas Aeruginosa, Staphylococus Aurcus, its potency was greater than that of norfloxacin, but less than ciprofloxacin; to mice infected by escherichia Coli, it is similar to norfloxacin. Its MIC (minimal inhibitory concentration) is between 0.063 and 16μg/ml for 314 specimem of 22 species. The MIC to 91.4% bacteris is 2 μg/ml or below. The results suggest that lomefloxacin aspartate is broad in antibacterial spectrum, strong in antibacterial activity.