SCLC与NSCLC中P-gp、CD44表达的差异

Differential expression of P - gp and CD44V6 in NSCLC versus SCLC

目的 探讨小细胞肺癌(SCLC)与非小细胞肺癌(NSCLC)多药耐药基因表达产物P-gp及细胞表面黏附分子CD44V6的表达差异。方法免疫组化SP法检测78例NSCLC与8例SCLC肿瘤组织中P-gp和CD44V6的表达,并分析其与临床病理指标的关系。结果SCLC中P-gp阳性率为50.00％,CD44V6阳性率为0,NSCLC中P-gp阳性率为79.49％,CD44V6阳性率为62.82％,P-gp及CD44V6在SCLC与NSCLC中表达率均有显著性差异(P<0.05,P<0.01)。NSCLC中CD44阳性组淋巴结转移率为53.85％,CD44V6阴性组淋巴结转移率为20.51％,差异有显著性(P<0.05)。结论P-gp和CD44V6的表达率在SCLC与NSCLC间存在显著差异,CD44V6的表达与NSCLC淋巴结转移有关,提示SCLC与NSCLC在化疗耐药和浸润转移机制上存在差异。

Objective To discuss the differences in P - gp and CD44 - v6 gene expressions between NSCLC and SCLC. Methods Iimmunohistochemical S - P method was used to examine the expression of P - gp and CD44 - v6 in 78 NSCLC and8 SCLC; their relationships with clinical and pathological features were analysed. Results The positive rates of P - gp and CD44V6 were 50% and 0 repectively in SCLC, and 79.49% and 62.82 % respectively in NSCLC, the differences were significant in P - gp ( P < 0,05) and CD44V6 ( P < 0.01) . The expression of CD44V6 was related to the lymph node melaslassis in NSCLC, with the CD44V6 positive rate being 53.85% in those with lymph node metastassis and 20.51% in those without (P < 0.05) . Conclusion There are differences in P- gp and CD44V6 expressions between SCLC and NSCLC. These discrepancies are related to the varied drug resistance and metastasis in SCLC and NSCLC.