硝酸异山梨酯联合用药的护理观察

Clinical Observation of Combined Use of Isosorbide Dinitrate on Angina Pectoris

目的 探讨硝酸异山梨酯联合用药对不稳定性心绞痛 (UA)的抗缺血作用。方法 5 7例不稳定性心绞痛患者随机分为 :硝酸异山梨酯联合用药组 (n =2 7) :在硝酸异山梨酯治疗UA的基础上加用环磷腺苷葡甲胺 (心先安 )、门冬氨酸钾镁 ,静滴 ,每d 1次 ,连续 10d ;对照组 (n =30 ) :给予常规UA治疗。比较治疗前后心绞痛发作及心电图所示的心肌缺血改善状况和心律失常的情况。结果 硝酸异山梨酯联合用药组心绞痛发作频率减少 ,间隔时间延长 ,心电图ST段下移恢复明显 ,心律失常发生率减少 ,与对照组比较均存在明显差异 (P <0 .0 5 )。结论 硝酸异山梨酯联合用药可以改善心肌缺血 ,减轻冠状动脉痉挛 ,减少心律失常的发生 ,副作用很少。

Objective To investigate the efficacy and side-effects of Isosorbide Dinitrate(ISD),Meglumine Cyclic Adenylate(MCA)and Potassium Megneim Aspartate(PMA)in patients with unstable angina pectoris(UA). Methods One hundred and five cases of UA were randomly divided into ISD plus group(treatment group,n=27) and control group (n=30). The total clinical effective rate and ECG changes were observed in both groups. Results The angina onset rate was rare and its interval prolonged. Also the ECG revealed that the descended S-T segments restored. The patients’ arrhythmia were fewer than before. All of the parameters were significantly different from the control group. Conclusions Isosorbide Dinitrate,Meglumine cyclic adenylate and Potassium Megneim Aspartate can improve myocardial ischemia,diminish coronary spasm and decrease arrhythmia with rare side-effects.