毛喉鞘蕊花中半日花烷型二萜成分的研究

Isolation and Identification of Labdane Diterpenoids from the Roots of Coleus forskohlii

目的 :研究毛喉鞘蕊花 (ColeusforskohliiBriq )根中的半日花烷型二萜类成分。方法 :乙酸乙酯提取 ,硅胶柱层析法和SephadexLH 2 0凝胶柱层析法分离化合物。运用IR、1HNMR、13 CNMR和 2DNMR光谱技术确定化合物结构。结果 :分得 7个 8,13 环氧 14 烯 11 酮半日花烷型二萜 ,分别为 6 乙酰佛司可林 ( 1)、1,6 二乙酰 7 去乙酰佛司可林 ( 2 )、1,6 二乙酰 9 去氧佛司可林 ( 3)、异佛司可林 ( 4 )、forskolinG( 5 )、forskolinH( 6 )和 6 β hydroxy 8,13 epoxylabd 14 ene 11 one( 7)。结论 :化合物 1～ 3为新天然产物 。

AIM:To isolate labdane diterpenoids from the roots of Coleus forskohlii and to elucidate the structures of them.METHOD:The chemical constituents were isolated by various column chromatographic analyses.The structures were elucidated on the basis of IR,MS, 1H NMR , 13 C NMR and 2DNMR experiments.RESULT: Seven diterpenoids were obtained and the structures were identified as 6-acetoxyforskolin(1),1,6-diacetoxy-7-deacetoxyforskolin (2),1,6-diacetoxy-9-deoxyforskolin(3),6-acetoxy-7 -deacetoxyforskolin(4),forskolin G(5),forskolin H(6) and 6β-hydroxy-8,13-epoxylabd -14-ene-11-one(7).CONCLUSION:Compounds 1～3 are new natural products.