多项血清学指标在肺癌患者中的应用价值

Applicated value of multi-serological index in lung cancer patients

目的:对肺癌患者进行七项血清学指标观察,探讨其在肺癌病程发展及治疗过程中的临床意义.方法:采用ELISA、IRMA和RIA法对肺癌组(273例)、慢性支气管炎组(179例)、正常对照组(193例)进行血清LN、sE-SLT、HA、CA242、NSE、CEA、AIF含量测定.统计学处理两组均数差别显著性分析采用t检验.结果:肺癌患者七项指标与正常对照组比较含量相差非常显著(P<0.01),而与慢性支气管炎比较LN、sE-SLT含量无显著性差异(P>0.05),HA、CEA、CA242、NSE、AIF含量明显升高(P<0.01).结论:上述结果提示LN和sE-SLT对于肺癌和慢性支气管炎的鉴别诊断无特异性,但与病情变化密切相关;HA、CEA、CA242、NSE、AIF则对于两种疾病的鉴别诊断具有一定参考价值,多项指标的联合检测对于肺癌的诊断、病情观察、判定疗效及预后有重要临床意义.

Purpose: 7 items serological index were obeserved in lung cancer patients. The clinical significance during the course of clinical development and treatment in lung cancer was explored. Methods? Contents of serum LN? sE-SLT? HA? CA242?NSE?CEA and AIF were detected by ELISA,IRMA and RIA methods in lung cancer group(273 cases)?chronic bron-chopneumonia group(179 cases) and control group(193 cases). Analysis of difference significance between two group mean adopt-ed t-tesx. Results: Compared with control group, contents of 7 items index in lung cancer patients have difference significantly (P<0. 01); compared with chronic bronchopneumonia group, contents of LN and sE-SLT have no difference significantly(P> 0. 05), contents of HA?CEA?CA242?NSE and AIF were increased significantly(P<0. 01). Conclusions: The results show LN and sE-SLT have no speciticity to distinguish Lung cancer from chronic bronchopneumonia, but relate to clinical development. HA?CEA?CA242?NSE and AIF have reference value to distinguish the two kinds of diseases. Detection of multi-serological in-dex have important clinical significance for diagnosis?observation of patient's condition?determiantipn of curative effect and prog-nosis in lung cancer.