抑癌基因与胃癌早期诊断

The relationship between tumor suppressor gene and early diagnosis of gastric carcinoma

目的:研究71例正常胃粘膜,胃粘膜炎症伴中、重度不典型增生、早期胃癌和进展期胃癌标本,了解肿瘤抑癌基因与胃癌的关系.方法:用免疫组化方法观察p21、p53和p16蛋白表达.结果:p21与p53的上调性阳性表达与不典型增生的程度有关,而P16呈下调性表达改变.结论:p21、p53及p16的表达异常与胃癌发生有关.检测这些指标可作为胃癌癌前病变的显著性标志.

Purposes:71 cases of normal gastric mucosa, gastric catarrh consisting with moderate or severe atypical hyperpla-sia,early and advanced gastric cancer were studied to explain the relationship between tumor suppressor genes and gastric carcino-ma. Methods:The abnormal expression of p21,p53 and p16 was detected by immunohistochemistry. Results: The up-regulated positive expression of p21 and p53 was associated with the atypical progress,whereas p16 was down 梤egulated. Conclusions:The expression of p21 ,p53 and p16 is related with the gastrocarcinogenesis. These molecules may be evaluated for their significance as markers of precancerous lesion.