摘要
目的;探讨食管癌患者的预后因素,了解食管癌细胞的增殖状态.方法:用Cox多因素回归模型对单纯根治性手术治疗的108例患者进行预后因素分析,并用许氏ABC法对其中50例患者的手术标本进行p53表达的检测.结果:食管癌患者的预后与临床分期、淋巴结转移和p53的表达有关(P<0.05);而与病变长度、部位、淋巴结大小、病理分级及弓上或弓下吻合无关(P>0.05).p53在食管癌中阳性表达率为54.0%(27/50),其表达强度与病理分级有关(P<0.05),而与临床分期无关(P>0.05).结论:食管癌患者的临床分期、淋巴结转移和p53的表达是重要的预后因素.
Purpose: In order to know the survial factors and proliferation state of esophageal carcinoma. Methods: 108 esophageal carcinoma patients which only accepted operation were analysed by Cox model,and expression of p53 was also detected in 50 of them by Avidinbiotin-peroxidase complex method. Results:The prognosis was correlated with clinical stage?nodal metas-tasis and intensity of p53,but there was no significant difference between prognosis and tumor location?length?pathologic grade? nodal size(P>0. 05).The positive rate of p53 was 54. 0%(27/50) in esophageal cancer,and its intensity was associated with pathologic grade(P<0. 05),but no-correlation with clinical stage(P>0. 05).Conclusion:The clinical stage?nodal metastasis and intensity of p53 are indications of the prognosis.
出处
《临床肿瘤学杂志》
CAS
1998年第4期7-9,共3页
Chinese Clinical Oncology
