摘要
目的:探讨p16/MTS1基因在子官内膜癌组织的表达及意义.方法:采用显微切割-聚合酶链反应方法,对29例子宫内膜癌组织和癌旁正常组织中p16/MTS1基因纯合缺失进行检测.并用Fisher精确检验的方法,对p16/MTS1基因纯合缺失与临床病理关系进行统计分析.结果:29例子宫内膜癌组织,p16/MTS1基因纯合缺失率为24.14%.Ⅰ期纯合缺失率为24.00%,Ⅱ期纯合缺失率为33.33%.结论:p16/MTS1基因纯合缺失与子宫内膜癌的发生有关.
Purpose:To probe the expression of pl6/MTSl gene in carcinoma of endometrium. Methods:Homozygous dele-tion of p16/MTSl gene was examined by micro-cut PCR methods in tissue from tumor cells and by side with normal tissue from 29 cases of carcinoma of endometrium, The ralation for clinical and pathology was analysed with Fisher excatest. Results: 24. 14% homozygous deletion of p16/MTSl gene was found in carcinoma of endometrium. Conclusions:There was an relation-ship between homozygous deletion of p16/MTSl gene and occurring of carcinoma of endometrium.
出处
《临床肿瘤学杂志》
CAS
1998年第4期10-12,共3页
Chinese Clinical Oncology