门冬氨酸钾镁预防阿霉素心脏毒性的临床研究

The clinical studies on the preventive effect of potassium magnesium aspaptate on the cardio-toxicity induced by adriamycin

目的:观察门冬氨酸钾镁(潘南金)对阿霉素所致心脏毒性的预防作用.方法:采用随机分组方法将53例入选病例分为门冬氨酸钾镁试验组(27例)与对照组(26例).治疗组于化疗前2天开始用门冬氨酸钾镁30～60ml加入5%葡萄糖液250～500ml中静滴,每日1次,直至化疗结束.对照组不用门冬氨酸钾镁,仅用普通药物.两组均以阿霉素为主联合化疗.结果:试验组患者化疗后无一例出现心脏毒性,对照组心脏毒性发生率为19.23%(5/26).结论:门冬氨酸钾镁对化疗中阿霉素所致心脏毒性有一定的预防作用.

Purpose:To study the preventive effect of potassium magnesium aspaptate(PMA) on the cardiotoxicity induced by adriamycin(ADM). Methods:53 patients with various cancer treated with adriamycin were divided at random into two groups: test group,27 cases,treated with PMA. Control group,26 cases,didn't inject PMA. Results:No one of the test group showed car-diotoxicity, but 5 cases in the control group showed electrocardiogram change. Conclusion:The results indicated that PMA had protective effect on the cardiotoxicity induced by ADM.