丝裂霉素、长春花碱酰胺和顺铂联合治疗晚期肺腺癌

Mitomycin vindesine, cisplatin combination chemotherapy in the treatment of advanced lung adenocarcinoma

目的:评价丝裂霉素、长春花碱酰胺和顺铂联合治疗晚期肺腺癌的疗效和毒性.方法:32例不能手术的肺腺癌Ⅲ～Ⅳ期,MVP方案化疗:丝裂霉素6mg/m^2,静脉冲入,第1、8天;长春花碱酰胺2.5mg/m^2,静脉冲入,第1、8天;顺铂60～80mg/m^2,静脉滴注,第3天,水化.每3周为一周期,二周期后评价疗效.结果:部分缓解率(12/32)40.6%.毒副反应主要为恶心、呕吐和白细胞下降.结论:MVP方案是治疗晚期肺腺癌疗效较高的方案.

Purpose:To evaluate the combined chemotherapy efficacy and toxicity of mitocycin, vindesine and cisplatin on ad-vanced lung adenocarcinoma. Method: 32 case of stage ? ~ IV lung adenocarcinoma were treated with MVP regimen unoperable , thatis mitomycin 6mg/m2, Vindesine 2. 5mg/m2,iv all seperatelly day 1,8. cisplatin 60~80mg/m2, iv drip, day 3, and enough solution need to be given intra venous infusion. The treatment was recycled every 21 days, and 3 cycles formed a theraputic couse. The theraputic effect was evaluated ofter 2 cycles. Results:Partial response rate (13/32) was 40. 6%. The main side-ef-fects were nausea, vomiting and leukopenia. Conclusion:The MVP regimen is regarded as a better regimen for advanced lung adenocarcinoma.