摘要
目前复合皮应用到临床上还有一定的难度，其原因之一是降低或消除异体真皮抗原性的效果还不理想，故还需进一步进行动物实验。我们选用Wistar大鼠做供体，SD大鼠作受体，进行皮片移植，以判断两者是否为同种异体。术后观察皮片存活情况，给织学变化，以及淋巴细胞增殖功能的测定。其结果显示，术后皮片均产生免疫排斥反应，故证实二种动物的组织相容性不同，无基因污染，能作为复合皮移植可靠的动物模型。
It's difficult that apply composite skin to clinicat present. One of reasons is uncertain resultabout decreasing or eliminating its antigen, so we continue do animal experiments, and used Wistar rats as donor, SD rats as receptor to do skin grafting, in order to judge that the antigen abouttwo kinds of rats whether is same or not. We observe the survival rate of grafting flap, histological changes, proliferation function of lymphocyte on POstoperation. The results showed that allo flaps grafted were rejected completely, so the MHC 11 antigen is different between two kinds ofrats. Its gene were not contaminated, and can be used as the reliable model of composite skin.
出处
《中国实验动物学杂志》
1998年第4期207-211,共5页
Chinese Journal of Laboratory Animal Science
基金
全军指令性课题!No.39070822
