马兜铃酸肾病的临床病理分析

Clinicopathological analysis of aristolochic acid nephropathy

目的 探讨马兜铃酸肾病的临床病理特点。方法 回顾性分析 3例马兜铃酸肾病患者的临床表现及病理资料。结果 2例急性马兜铃酸肾病临床表现为 :消化道症状、肾功能减退、尿酶升高、电解质紊乱 ;病理诊断为急性肾小管坏死。1例慢性马兜铃酸肾病临床表现为 :贫血、尿检异常、高血压、肾功能减退 ,病理诊断为慢性间质性肾炎。结论 含有马兜铃酸的中药有肾损害 ,可致马兜铃酸肾病 。

Objective To probe into the clinicopathological features of AAN.Methods Clinicl and pathological data of 3 cases with AAN were retrospectively analyzed.Results Clinically,two patients with acute AAN were characterized by gastrointestinal symptom,renal insufficiency,high urine enzyme and electolyte disorder.Pathological diagnosis was acute tubuler necrosis.The patient with chronic AAN was clinically characterized by anemia,abnormality of urine,hypertension and renal insufficiency.Pathological diagnosis of the patient was chronic interstitial nephritis.Conclusion Chinese herbs containing aristolochic acid are related to kindney lesion and could cause AAN which presents unique characteristic clinicopathology.