化学修饰酶的研究进展

Study and Progress of Chemical Modification Enzyme

化学修饰已成为改进酶的物理化学性能、提高其生物活性的有效方法。着重介绍化学修饰酶的研究与进展,并对其发展进行了展望,主要内容包括交联技术、定点突变和化学修饰结合技术、小分子修饰、单功能聚合物化学修饰、辅因子引入。综述了各种化学修饰方法的特点和应用。

Chemical modification is an effective method that improve the physical and chemical character and activity of the enzyme. This paper includes enzyme crosslinking, site-directed mutagenesis, small molecular compounds, homo-functionality polymerization, cofactor introduction. The characteristics and application of chemical modification are summarized.