山高粱水提物对大鼠急性肝损伤保护作用的研究

Protective Effects of Sorbaria sorbifolia aqueous Extract on Carbon Tetrachloride Induced Acute Hepatic Injury in Rats

目的 :研究山高粱水提物对 CCl4 所致大鼠急性肝损伤的保护作用。方法 :给动物灌胃给药 ,用 CCl4 造大鼠急性肝损伤模型 ,用比色分析法测定大鼠血清天冬氨酸转氨酶 (aspartate transaminase,AL T)、丙氨酸转氨酶 (alaninetransaminase,AST)的活性 ;测定大鼠血清超氧化歧化酶 (superoxide dismutase,SOD)、谷胱甘肽过氧化物酶 (glutathioneperioxidase,GSH- PX)的活性及丙二醛 (malondialdehyde,MDA)的含量。结果 :山高粱水提物显著降低因 CCl4 所致急性肝损伤大鼠血清 AL T的升高 ;对急性肝损伤大鼠血清 SOD,GSH- PX的活性有明显的升高作用及降低 MDA的含量 (P<0 .0 1或 P<0 .0 5 )。结论 :山高粱水提物对 CCl4 所致大鼠急性肝损伤有保护作用。

Objective:To study the protective ef fe cts of Sorbaria sorbifolia aqueous extract on carbon tetrachloride induced acut e hepatic injury in rats.Methods:The aqueous extract of Sorbaria sorbifolia was pe rfused into stomach to the rats with induced acute hepatic injury by carbon tetr achloride. The activities of aspartate transaminase(AST), alanine transaminase(A LT),superoxide dismutase(SOD) , glutathione perioxidase(GSH-PX); and the content of malondialdehyde(MDA) were investigate using colorimetric measured.Results:The aqueous extract of Sorbaria sorbifolia signifi cantly reduced acute hepatic injury by carbon tetrachloride, by means of decreas ing ALT and AST in serum; the activities of SOD, GSH-PX in treat group were hig her than that of model group and the content of MDA in treat group was lower th an in model group, respectively. Conclusion:The aqueous extract of Sorbaria sorbifolia has protecting effects for rats acute hepatic injury by carbon tetrachloride.