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5-脂氧合酶与脑缺血再灌注 被引量：2

5-Lipoxygenase and Cerebral Ischemic Reperfusion
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摘要 5 脂氧合酶 (5 lipoxygenase,5 LO)是催化花生四烯酸转化为白三烯的关键酶。研究表明 ,5 LO参与了Alzheimer病、脑血管病、癫和脑肿瘤等多种神经系统疾病的发生和演变过程。脑缺血再灌注时 ,5 LO的表达增加可能促进了神经细胞死亡。 lipoxygenase (5 -LO) is a key enzyme in the conversion of arachidonic acid into leukotrienes. S tudies have shown that 5-LO involved in the occurrence and development of neuro logical diseases, such as Alzheimer's disease, cerebrovascular diseases, epileps y and brain tumors. The increased expression of 5-LO in cerebral ischemia-repe rfusion may facilitate the death of nerve cells.
作者 曹立梅 毕桂南
机构地区 广西医科大学附属第一医院神经内科
出处 《国外医学（脑血管疾病分册）》 2004年第11期850-853,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 脑缺血再灌注 5-脂氧合酶 白三烯 神经细胞死亡 ALZHEIMER病 神经系统疾病 脑肿瘤 关键酶 花生四烯酸 转化 lipoxygenase ■ brain ischemia ■ reperfusion
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献17

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同被引文献28

  • 1金江丽.2005年卒中和脑血管疾病的遗传学研究进展[J].中国卒中杂志,2006,1(2):146-147. 被引量：2
  • 2张伟丽,石佳,杨晓敏,孙凯,惠汝太.ALOX5 AP基因多态2354T/A和MTHFR基因多态677C/T的协同作用显著增加脑梗塞的易患性[J].中国分子心脏病学杂志,2005,5(1):395-400. 被引量：9
  • 3Chu J, Pratic b D. 5-1ilxxygena. as ar endogenous rnodulalor of anyloid [3 formation in vivo [J]. Ann Neurol, 201 |, 69 (l): 34-46.
  • 4Chinnici CM, Yao Y, Pratic 1). The 5-1ipoxygenase enzymatic pathway in the mouse brain: young versus old[J]. Neurobiol Aging, 2007, 28: 1457-1462.
  • 5Taisuke T. Seeretase inhibitors and modulato for Alzheimer's disease treatment/J]. Expert Rev Neurother, 2009, 9(5): 661-679.
  • 6Amniai L, Barbier P, Sillen A, et al. Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but nol binding to microtubules[J]. The FASEB Journal, 2009, 23(4): 1146- 1152.
  • 7Avila J. Tau kinases and phosphatases[J]. J Cel Mol Med, 2008, 12(1): 258-259.
  • 8Qu T, Manev R, Manev H. 5-Lipoxygenase (5-LOX) protrter palyrrgtp}tism in patients with early-onset and late-onset Alzheimer's disease[J]. J Neuropsyehiatry Clin Neurosci, 2001, 13: 304-305.
  • 9Chu J, Phillip F, Golde TE, et al. Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice[J]. Mol Neurodegenerat, 2012, 7 (1): 1.
  • 10Oddo S, Caccamo A, Tseng B, et aL Blocking Aheta 42 accumulation delays the onset and progression of tau pathology via the C terminus of the heat shk protein 70-interacting protein: a mechanistic link between Abeta and tau pathology[J]. J Neurosci, 2008, 28: 12163-12175.

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国外医学（脑血管疾病分册）
2004年 第11期

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