纤维蛋白原B_β单核苷酸多态性与缺血性脑血管病
Single Nucleotide Polymorphism of Fibrinogen B_β Gen e and Ischemic Cerebrovascular Diseases
摘要
纤维蛋白原 (Fg)是缺血性脑血管病的重要危险因素 ,FgBβ肽链的合成是Fg合成的限速步骤。文章介绍了目前已发现的FgBβ基因多态性 ,以及其与血浆Fg水平和缺血性脑血管病的关系。
Fibrinogen is an i mportant risk factor for ischemic cerebrovascular diseases. The synthesis of fib rinogen Bβ peptide chain is the rate-limiting step of fibrinogen synthesis. Th e article describes the recently found fibrinogen Bβ gene polymorphism and its relationship with the level of plasma fibrinogen and ischemic cerebrovascular di seases.
出处
《国外医学(脑血管疾病分册)》
2004年第11期862-865,共4页
Foreign Medical Sciences Cerebrovascular Diseases
参考文献38
-
1Laragh JH. Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke). J Hum Hypertens, 19
-
2van't Hooft FM, Silveira A, Tornvall P, et al. Two common, functional polymorphisms in the promoter region of the beta-fibrinogen gene contribute to regulation of plasma fibrinogen concentration. Arterioscler Thromb Vasc Biol, 1999, 19:3063 -3070.
-
3Humphries SE, Ye S, Talmud P, et al. European Atherosclerosis Research Study: genotype at the fibrinogen locus (G-455-A beta-gene)is associated with differences in plasma fibrinogen levels in young men and women from different regions in Europe. evidence
-
4Kain K, Catto AJ, Young J, et al. Increased fibrinogen, yon Willebrand factor and tissue plasminogen activator levels in insulin resistant South Asian patients with ischaemic stroke. Atherosclerosis,2002, 163:371 -376.
-
5Margaglione M, D'Andrea G, Giuliani N, et al. Inherited prothrombotic conditions and premature ischemic stroke: sex difference in the association with factor V Leiden. Arterioscler Thromb Vasc Biol, 1999, 19:1751 - 1756.
-
6Behague I, Poirier O, Nicaud V, et al. β fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM Study.Etude Cas-Temoins sur l'Infarctus du Myocarde. Circulation, 1
-
7Carter AM, Catto AJ, Bamford JM, et al. Gender-specific associations of the fibrinogen B β 448 polymorphism, fibrinogen levels, and acute cerebrovascular disease. Arterioscler Thromb Vasc Biol, 1997,17: 589 - 594.
-
8Thomas A, Lamlum H, Humphries SE, et al. Linkage disequilibrium across the fibrinogen locus as shown by five genetic polymorphisms, G/A-455 (HaeⅢ), C/T-148 (HindⅢ/AluI), T/G + 1689(AvaⅡ), and BclⅠ(β-fibrinogen) and TaqⅠ(α-fibrinogen), and their det
-
9Green F, Hamsten A, Blomback M, et al. The role of β-fibrinogen genotype in determining plasma fibrinogen levels in young survivors of myocardial infarction and healthy controls from Sweden. Thromb Haemost, 1993, 70:915 -920.
-
10Kessler C, Spitzer C, Stauske D, et al. The apolipoprotein E and β-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease. Arterioscler Thromb Vasc Biol, 1997, 17:2880 -2884.
-
1陈远俊.急性缺血性脑卒中患者预后与血清尿酸水平的关系与分析[J].广东医学院学报,2008,26(4):387-389. 被引量:4
-
2周国平,靳守华.东菱迪芙治疗不同时间脑梗死的疗效观察[J].中国水电医学,2005,0(3):137-138.
-
3帕金森病蛋白质的改变是否为其病因?[J].德国临床用药,1998,1(2):39-40.
-
4张海霞,杨美荣,张江,陈乃耀,王大力.急性脑梗死与血浆Fg水平以及FgBβ-455G/A多态性的相关性研究[J].山东医药,2011,51(4):23-24. 被引量:1
-
5何伟,王桂斌.神经元特异性烯醇化酶在神经疾病中的应用价值[J].医学综述,2008,14(21):3227-3229. 被引量:17
-
6宋秀娟,郭力,李彬,张静,董惠.肿瘤坏死因子β基因多态性与多发性硬化的相关性研究[J].中国神经精神疾病杂志,2008,34(2):76-78. 被引量:5
-
7张奇志,王言森,吕舒仪,魏明芬,孟海燕.冠心病患者FgBβm RNA表达及蛋白质水平变化的临床意义[J].山东医药,2004,44(25):41-42.
-
8吕明恩,汪家敏,白霞,王兆钺,阮长耿.脑梗死患者血小板糖蛋白Ibα kozak序列多态性研究[J].江苏医药,2003,29(10):781-782. 被引量:6
-
9江震钦,纪虹,叶志其,张国忠.肿瘤坏死因子α及β基因多态性与多发性硬化关系的研究[J].中华神经医学杂志,2006,5(6):572-575. 被引量:3
-
10孙庆利,樊东升,孙阿萍,寿延红,傅瑜,李小刚,谢汝萍.中国多发性硬化患者肿瘤坏死因子β基因多态性的Meta分析[J].中国神经免疫学和神经病学杂志,2011,18(4):250-252. 被引量:1