西酞普兰与氟西汀治疗抑郁症对照研究

A clinical controlled study of citalopram and fluoxetine in the treatment of depression

目的 :比较西酞普兰与氟西汀治疗抑郁症的疗效及不良反应。 方法 :5 7例抑郁症患者被随机分为西酞普兰组 (2 9例 )和氟西汀组 (2 8例 )进行为期 6周的治疗。以汉密尔顿抑郁量表 (HAMD)、副反应量表 (TESS)于治疗前及治疗 1、2、4、6周末分别评定疗效和不良反应。 结果 :西酞普兰组显效率为 72 .4 % ,氟西汀组为 71.4 % ,两组间比较差异无显著性。两组HAMD评分于治疗 1、2周末差异有显著性 ,提示西酞普兰起效较早。治疗后各周两组间TESS评分比较差异均无显著性。 结论 :西酞普兰和氟西汀均有良好的抗抑郁效果。西酞普兰具有起效早。

Objective:To compare the clinical efficacy and the side effects between citalopram and fluoxetine in the treatment of depression. Method:57 patients with depression were randomly assigned to citalopram group (n=29) and fluoxetine group (n=28) for six-weeks.The effects and side reactions were evaluated respectively with Hamilton depression scale (HAMD) and treatment emergent symptoms scale (TESS). Results:The clinical therapeutic efficacy in two groups were both significantly well andthere was no significant difference between them.The difference in HAMD marks between the two groups in the first and the second week after treatment was significant and this meant that citalopram had an earlier beginning time of efficacy.At every week,there were no significant differences in TESS between two groups. Conclusion:Citalopram and fluoxetine are both good drugs in the treatment of depression.Citalopram takes effects quickly and has light side effects.