发作性睡病猝倒型患者与快眼动睡眠的关系

Relation between REM advance and cataplexy in patients with narcolepsy

目的 探讨发作性睡病猝倒发作与快眼动睡眠 (REM)的关系。方法 采用白天多次睡眠潜伏期试验(MSLT)和整夜多导睡眠图(PSG)描记方法对 27例猝倒型和 21例非猝倒型发作性睡病患者进行相关睡眠指标分析。结果 猝倒组入睡次数(3. 82±0. 73)和入睡初REM提前出现次数 (2. 48±0. 80)明显高于非猝倒组(P<0. 01),睡眠潜伏期比较差异无显著性 (P>0. 05);夜间睡眠时间减少和睡眠效率降低,两组比较差异有显著性(P<0. 05)。结论 发作性睡病伴猝倒与REM提前有关。

ObjectiveTo explore the relation between REM advance and cataplexy paroxysm in patients with narcolepsy . Methods Multiple sleep latency test(MSLT) in daytime and polysomnography(PSG) in nights were recorded in 28 cataplexy and 21 without cataplexy by relate sleep index ,and the results were compared. ResultsAs compared with without cataplexy group , the cataplexy group showed increased sleep frequency(3.82±0.73) and sleep onset REM periods(SOREMP)( 2.48±0.80) on MSLT, there was a significant difference(P<0.01), and no significant difference in the sleep latency changes (P>0.05) ;the sleep time and sleep efficiency of cataplexy group were lower than those of without cataplexy group(P<0.05).Conclusion The cataplexy paroxysm might be closely related to the inbreak of REM.