脑立体定向手术治疗难治性精神分裂症及手术前后因子分析

Apply brain stereotactic operation to treat refractory schizophrenia and to analysis using factors before and after operation

目的 评价用简明精神评定量表 (briefpsychiatricratingscule,BPRS)及各因子分评定脑立体定向手术治疗难治性精神分裂症的效果。方法 对 37例难治性精神分裂症病人 ,采用立体定向扣带回、杏仁核、内囊前肢等脑内核团进行毁损 ,并在手术前后进行BPRS及各因子分评定。结果 术后综合疗效评定 :优 4例 ,显进 16例 ,进步 15例 ,无效 2例。手术前后BPRS及各因子分析显示BPRS总分、活动过多、敌意猜疑手术前后对照有显著的差异性 (P <0 .0 1)。结论 BPRS及各因子分可作为脑立体定向手术治疗难治性精神分裂症效果评定的量化指标和选择手术病人的客观依据。

Objective To study the operative effect of brain stereotactic operation in treating refractory schizophrenia using brief psychiatric rating scule(BPRS )and other factors.Methods 37 patients with refractory schizophrenia were performed selective amygdala and cingulate gyrus lesions through brain stereotactic technology.They were assessed using BPRS and other factors before and after operations.Results The general efficacy assessment after operation showed cure in 4,marked immarked improvement in 16,improvement in 15, and no improvement in 2.The analysis using BPRS and other factors before and after operations showed:there were significant differences ( P <0.01) in BPRS、Thought Disturbance(THOT)、Activution(ACTV) and Hostiele-suspiciousness(HOST).Conclusion BPRS and other factors can be used as assessment indes and selective calibration in treating patients with refractory schizophrenia using brain stereotactic operation.