螺内酯对冠心病患者内皮细胞功能的影响

Effect of antisterone on endothelial cell function in coronary heart disease

目的 本实验旨在探讨螺内酯对冠心病患者内皮细胞功能的影响。方法 选择 5 0例冠心病患者作为实验组 ,5 0例健康者作为对照组 ,给药前先测定实验组和对照组的内皮素 (ET)、血栓素 A2 (TXA2 )、一氧化氮 (NO)、前列环素 (PGI2 ) ,再予以实验组螺内酯 2 0 m g/ d,3个月后再测定实验组的 ET、TXA2 、NO、PGI2 并进行比较。结果 给药前实验组的 ET、TXA2 水平较对照组高 ,NO、PGI2 水平较对照组低 ;给药后 NO、PGI2 水平较给药前高 ,ET、TXA2 较给药前低。结论 螺内酯可以有效地改善血管内皮细胞功能 ,对逆转冠心病患者内皮细胞功能紊乱起着重要的作用。

Objective To investigate the effect of antisterone on the function of endothelial cell. Methods 50 coronary heart disease patients were selected in experiment group and 50 healthy people as a control group. ET,TXA 2,NO,PGI 2 levels were tested in both groups, then antisterone 20mg were taken once a day, and all the indexes after 3 months were tested. Results Before taking antisterone, ET and TXA 2 levels of experiment group were higher than that of control group, NO and PGI 2 levels in experiment group were lower than that of control group. After taking antisterone, NO and PGI 2 levels were increased and ET and TXA 2 levels were decreased. Conclusion Antisterone can effectively improve the function of blood vessel endothelial cell, and plays important role in reversing the dysfunction of endothelial cell in coronary heart disease.