新生儿多器官功能障碍时胃肠功能衰竭的临床研究

The Retrospective Investigation of Multiple Organ Dysfunction Syndrom of Newborn with Gastrointestinal Function Failure

目的探讨新生儿多器官功能障碍(MODS)与胃肠功能衰竭的关系,寻求有效的防治措施。方法对方我院68例患有MODS新生儿的临床资料进行回顾性分析,评估新生儿MODS时胃肠功能衰竭的临床特点。结果68例结MODS患儿胃肠功能衰竭发生率为55.88%(38/68),具有2、3、4个或以上器官功能障碍的患儿,胃肠功能衰竭发生率依次为22.73%(5/22)、60.71%(17/28)、88.89%(16/18),各组有显著性差异(x2=18.0284,P<0.01)。胃肠功能衰竭组病死率为52.63%(20/38),非胃肠功能衰竭组病死率为23.33%(7/30),两组相比有显著性差异(x2=6.0110,P<0.05).结论MODS新生儿,胃肠功能衰竭发生率高,并且受损器官数目越多,胃肠功能衰竭发生率越高。MODS新生儿出现胃肠功能衰竭病死率比非胃肠功能衰竭组明显增高。因此胃肠功能衰竭在MODS中占重要位置。如果及时有效控制其发展,阻断其它器官相继序贯性衰竭对MODS转归和预后及降低病死率有重要意义。

Objective To study the relationship between the multiple organ dysfunction syndrom(MODS) of newborn and gastrointestinal function failure (GIF) for a better treatment. Methords Clinical data of 68 MODS newborns were retrospectively analyzed to estimate the relationship between MODS of newborn and gastrointestinal function failure. Results The morbidity rate of GIF in the subjects with 2,3, and ≥4 organs failure were 22.73%(5/22),60.71%(17/28),88.89%(16/18) respectively.These differences were significant(x2=18.0284,P<0.0.1).After multiple methords treatment the fatality rate of with GIF groups and with no GIF groups were 52.63%(20/38), 23.33%(7/30) respectively. The difference was significant(x2=6.0110,P<0.05).Conclusion There is a high morbidity rate of GIF newborn with MODS.And the more number of organ failure accompanied,the higher the morbidity rate of GIF. The fatality rate with GIF groups is higher than with no GIF groups.Therefore GIF plays an important role in the newborn MODS. If treat it timely and effectly to avoid the other organs failure in sequence,it will be greatly benefit for the prognose of MODS.