血清降钙素原检测对院内深部真菌感染诊断价值的探讨

Diagnostic Value of Serum Procalcitonin for Nosocomial Deep Mycotic Infection in Critically ill Patients

目的 :探讨血清降钙素原 (PCT)检测诊断危重病患者院内深部真菌感染 (IMI)的价值。方法 :回顾性分析重症监护病房内 5 6例临床资料 ,并与健康组 15例对照。结果 :IMI组较健康对照组血清PCT水平明显升高 (P <0 .0 1)。不同感染部位 ,以血液真菌感染者PCT水平最高 (P <0 .0 1)。但PCT不能鉴别不同真菌菌株。结论 :PCT可作为危重病患者院内IMI有价值的诊断指标。

Objective:To evaluate the diagnostic value of procalcitonin (PCT) in critically ill patients with nosocomial invasive mycotic infection (IMI). Methods: 56 critically ill patients with IMI in intensive care unit were retrospectively analyzed. Results: The PCT levels of patients with IMI were significantly higher than those of control group (P<0.01). The PCT levels of patients with fungemia was the highest among the different locations of mycotic infection (P<0.01). PCT was unable to differentiate different fungal strains. Conclusion: The measurement of PCT might be used as a valuable index in diagnosis of nosocomial deep mycotic infection in critically ill patients.