测定盐酸氟桂嗪的电位型漆酚树脂化学传感器研究

Study on the Urushiol Potential Chemical Sensor for the Determination of Flunarizine Hydrochloride

以漆酚树脂为载体,研制了测定医用药品盐酸氟桂嗪的电位型化学传感器。基于不同的离子缔合物、含量及增塑剂对传感器性能的影响,采用正交设计法综合考察它们的交互作用,筛选了敏感膜的组成,测试了传感器性能。结果表明:以盐酸氟桂嗪(FHC)-漆酚树脂离子缔合物为电活性物质,DBP∶DOP=1∶1.5(质量比)为增塑剂制成的PVC敏感膜性能最佳,其线性范围1.0×10-3～5.0×10-6mol/L,检测下限3.5×10-6/L,响应斜率为59.0mV(25°C);传感器的选择性、重现性和稳定性良好,以本传感器对市售医用盐酸氟桂嗪胶囊剂含量进行测定,其结果与紫外分光光度法基本一致。

A potential chemical sensor used for the determination of a kind of medicine-flunarizine (hydrochloride) was reported. The sensor uses urushiol resin as a carrier. The result shows that the PVC (sensing) mould with FHC-urushiol resin ion association complex as the electric active substance and the plasticizer mass ratio of DBP∶DOP=1∶1.5 has the best performance the sensor shows a response slope of 59.0 mV over the linear range of 1.0×10^(-3)～5.0×10^(-6) mol/L. The detection lower limit is 3.5×10^(-6) mol/L. It has good selectivity. repeatability and stability. The sensor has been used to determine commercial samples and the average recovery is 99.0%.