肝病患者血清丙型肝炎病毒抗体检测及其临床意义

Serodiagnosis for Anti-HCV in 304 Liver Diseases Inpatients

采用国产抗-HCV试剂盒,对304例各类肝病患者血清标本进行了检测(ELLSA法),同时对100例健康献血员作为对照。结果表明,对照组无检出,肝病组抗-HCV检出率31.25％(95/304)。该95例中:1)单纯抗-HCV阳性者17例(5.59％);2)与HBV混合(重叠感染)者68例(22.36％),其中肝硬化、重型肝炎和活动性肝炎较多,分别为35例、9例和8例,提示HCV与肝脏慢性纤维化及肝衰患者有密切关系。304例中输血后肝炎17例100％抗-HCV阳性,上述68例C、B型混合感染中,有输血史者亦达45例(约占2/3),均说明我国输血后肝炎主要由HCV引起。

304 inpatients with various liver diseases/hepatitis were tested for anti-HCV by Serodiagnosis using the ELISA method. The results showed that, the total anti-HCV seropositivity rate was 31.25% (95/304).Of the 95 positive cases, 1) 17 (5.59%) were solely anti-HCV positive; 2) 68(22.36%) co-infection/super-infection cases were anti-HCV & HBV-marker positive, of which, LC, serious severe hepatitis and CAH were comparatively more in number, being 35, 9, and 8 respectively, suggesting that HCV was closely associated with chronic fibrosis of liver and liver failure, of the 304 total, 17 blood transfusion hepatitis cases were 100% anti-HCV positive, and also, the above 45 of 68 HCV-HBV coinfection cases had blood transfusion history(2/3approximately), both situations confirming the inference that, domestically, blood transfusion hepatitis seemed to be induced mainly by HCV.