母乳性黄疸的临床干预探讨

Clinical study on the management of breast milk jaundice

目的 探讨母乳性黄疸的诊断和干预措施。方法 随机将母乳性黄疸婴儿分成对照组 (D组 ,2 0例 )和治疗组 (A、B、C组 )。治疗组分别服用鲁米那 (A组 ,2 0例 ) ,枯草杆菌肠球菌二联活菌多维颗粒剂 (B组 ,2 0例 )、鲁米那 +枯草杆菌肠球菌二联活菌多维颗粒剂 (C组 ,4 9例 ) 5～ 7d ,检测治疗前后血清总胆红素。结果 治疗组治疗后血清胆红素值均有下降。A组从 (139.79± 33.14 ) μmol/L降至 (10 1.6 6± 38.13) μmol/L(P <0 .0 5 ) ;B组从 (136 .4 6± 38.2 4 ) μmol/L降至 (83.19± 35 .6 6 ) μmol/L(P <0 .0 0 1) ;C组从 (14 4 .37± 5 2 .2 5 ) μmol/L降至 (5 5 .31± 4 6 .0 1) μmol/L(P <0 .0 0 1) ;C组血清胆红素下降最显著。结论 鲁米那或枯草杆菌肠球菌二联活菌多维颗粒剂均可降低母乳性黄疸婴儿的血清胆红素 ,但二者联合应用效果更好 ;母乳性黄疸不必停母乳 ,可用药物进行干预治疗。

Objective To explore diagnosis and management of breast milk jaundice.Methods Newborns with breast milk jaundice were divided into four groups:group B,group C and group D (control).The former three groups took Luminaletten (group A)、Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines (group B)、Luminaletten and Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines (group C) 5～7 days respectively.Serum total bilirubin was tested before and after treatment.Results All three treated groups had serum total bilirubin significantly decreased (P<0.05),among them group C decreased the most.Conclusions Both Luminaletten or Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines can lower the serum total bilirubin level of the newborns with breast milk jaundice.Taking two of them is the most effective.The diagnosis of breast milk jaundice depends on history and effects of Luminaletten and Live Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines intervention.Too many laboratory tests for evaluating breast milk jaundice are unnecessary and breast feeding should not be stopped.