湖北地区人群的CYP2D6二倍体多态性基因分析

Analysis of CYP2D6 gene duplication of Chinese population in Hubei

使用长模板PCR方法检测 2 2 3例湖北地区人群中CYP2D6二倍体 .在被检人群中 ,CYP2D6二倍体的基因频率为 2 .7% .检测到 6例CYP2D6二倍体 ,基因型分别为 1× 2 (3/ 6 ) , 2× 2 (2 / 6 ) ; 10× 2 (1/ 6 ) .

The Expand TM Long Template PCR assay was used to detect the CYP2D6 gene duplication of 223 DNAs from volunteers in Hubei. In sampled 223 Chinese, the frequency of CYP2D6 gene duplication was 2.7?%. Six CYP2D6 gene duplication were detected, and the genotypes of duplication were *1×2(3 of 6), *2×2(2/6) and *10×2(1/6), respectively. The frequency of CYP2D6 gene duplication was slightly higher than that in other Orientals. A new CYP2D6 duplication, *10×2 was detected firstly, indicating the genetic diversity of people in Hubei compared with people from other regions in China.