一个临床试验模型中的参数检验和估计改进

Test and estimation improvement for parameters in a clinical trial model

讨论有不服从发生时,临床试验数据EV模型中的参数估计和检验问题.在以前结果的基础上,文中给出模型中公共参数的一个改进估计,提出了一个药物治疗效果的检验方法.最后通过模拟研究考察上述估计和检验的效果.

This paper studies the estimation and testing of parameters in a clinical trial model with noncompliance.Based on the previous results,an improved estimator of the common parameter is presented,and a testing for the parameter reflecting the efficacy of treatment is proposed.Finally,a simulation study is conducted to illustrate performance of the above estimator and test.