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对羟基苯硼酸频哪醇酯的合成 被引量：2

Synthesis of Pinacol 4-Hydroxyphenyl Boronate
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摘要 用叔丁基二甲基氯硅烷保护对溴苯酚的酚羟基,制成Grignard试剂后与硼酸三甲酯反应制得对叔丁基二甲基硅氧基苯硼酸二甲酯,再与频哪醇进行酯交换反应后脱去保护基得到对羟基苯硼酸频哪醇酯,总收率28.2%。 Pinacol 4-hydroxyphenyl boronate was synthesized in 28.2% overall yield from 4-bromophenol by protection with t-butyldimethylsilyl chloride, Grignard reaction and reaction with B(OCH3)3 to afford dimethyl t-butyldimethylsilyloxyphenylboronatefollowed by ester exchange with pinacol and then deprotection.
作者 晁建平 武文琼 罗宣德 凌仰之
机构地区 北京大学药学院药化系 中国药物研究开发中心
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2004年第12期712-713,共2页 Chinese Journal of Pharmaceuticals
基金 国家自然科学基金资助项目(017110)
关键词 对羟基苯硼酸频哪醇酯 中间体 合成 pinacol4-hydroxyphenylboronate intermediate synthesis
分类号 O625.312 [理学—有机化学]
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参考文献11

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同被引文献23

  • 1迟会伟,李志念,刘长令.啶酰菌胺的合成与生物活性研究[J].精细化工中间体,2007,37(4):14-16. 被引量：24
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中国医药工业杂志
2004年 第12期

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