2,4,5-三氟苯甲酸的合成

Synthesis of 2,4,5-Trifluorobenzoic Acid

用2,4-二氯-5-氟苯甲酸和氯化亚砜反应得到的酰氯,经氨水酰胺化后脱水生成2,4-二氯-5-氟苄腈,再经氟代、水解制得2,4,5-三氟苯甲酸,总收率46%。

Trifluorobenzoic acid was synthesized from2,4-dichloro-5-fluorobenzoic acid by chlorination, amidation and dehydration to give2,4-dichloro-5-fluorobenzylcyanide, which subjected to fluorination and hydrolysis with an overall yield of 46%.