聚乙二醇催化合成取代苯氧乙酸

Synthesis of Substituted Phenoxyacetic acids by PEG Catalyzing

以水为溶剂,聚乙二醇-800为催化剂,苯酚的衍生物与氯乙酸在碱性条件下加热回流制备取代苯氧乙酸。当反应物的浓度是3.5 mol/L,苯酚衍生物与氯乙酸的摩尔比是1:1.1,反应时间是1 h,合成了5种取代的苯氧乙酸,都获得了高产率,其中,4-氯苯氧乙酸产率95.2%,2,4-二氯苯氧乙酸产率91.4%。

Substituted phenoxyacetic acids were prepared from reaction of phenol derivatives and chloroacetic acid by PEG catalyzing in alkaline water. When the concentration of mixture was 3.5 mol/L, the mole ratio of phenol derivatives and chloroacetic acid was 1:1.1, and with refluxing 1h, the high yield of products was obtained.