表皮生长因子受体在胰腺癌组织中的表达及意义

The Expression of EGFR and clinical significance in pancreatic carcinoma

目的 :探讨表皮生长因子受体 (epidermal growth factor receptor,EGFR)在胰腺癌组织中的表达与临床病理因素的关系。方法 :用免疫组织化学方法检测 3 1例胰腺癌及对应癌旁组织中 EGFR的表达水平。结果 :3 1例胰腺癌中 EGFR的阳性表达 2 1例(67.74% ) ,明显高于对应癌旁组织 ;胰腺癌中 EGFR的表达水平与胰腺癌的神经浸润转移密切相关 (P<0 .0 5 )。结论 :与对应癌旁组织相比 ,胰腺癌组织中的 EGFR表达水平明显上升 (P<0 .0 5 ) ,EGFR表达水平的改变可作为提示胰腺癌神经浸润转移的一个指标。

Objective:To study the expression of EGFR in pancreatic carcinoma and its relation with clinical pathological parameters.Methods:Expression of EGFR was examined by immunohistochemical method.Results:The positive rate of EGFR is 67.74%,which is significantly higher than that of matched normal tissue;The expression level of EGFR in pancreatic carcinoma was related to nervous infiltration(P<0.05).Conclusion:Compared with matched normal tissue,the expression of EGFR in pancreatic carcinoma was higher(P<0.05).The increased expression of the protein may be an indicator of nervous infiltration.