摘要
目的 :观察血管紧张素受体拮抗剂缬沙坦对肾病综合征大鼠的干预保护作用。方法 :建立大鼠阿霉素肾病模型 ,应用放射免疫分析法检测血浆及肾组织白细胞介素 8含量。结果 :阿霉素肾病大鼠血浆白细胞介素 8含量有所增高 ,血管紧张素受体拮抗剂对肾病综合征大鼠血浆及肾组织白细胞介素 8含量均无明显影响。结论 :白细胞介素 8通过细胞因子间的相互作用参与肾病的形成、发展 ;血管紧张素受体拮抗剂缬沙坦对肾病综合征大鼠的干预保护作用似与改变局部白细胞介素 8含量无关。
Objective:To observe the role of Angiotensin II receptor antagonist valsartan on kidney of rat with nephrotic syndrome.Methods:The rats with adriamycin nephrosis were treated with angiotensin receptor antagonist , valsartan.The concentration of interleukin-8 (IL-8) plasma and renal tissue were measured by radioimmunoassay.Result:The concentration IL-8 of rats with adriamycin nephrosis were higher than the control group; In valsartan treated rat, the concentration of IL-8 in plasma and renal tissue were not reduced than untreated rat. Conclusion:IL-8 may play a part in renal damage in adriamycin nephrosis.The protective effect of valsartan on rat with adriamycin nephrosis seems hardly relevant to the local change of IL-8 concentration.
出处
《南通医学院学报》
2004年第4期397-398,共2页
ACTA Academiae Medicinae Nantong
基金
江苏省卫生厅课题 (Z990 5 )
