摘要
本文观察了一次性经腹腔注射氯乙醇（３０ｍｇ／ｋｇＢ．Ｗ．）的急性染毒大鼠３，６，１２，２４ｈ等四个不同时点肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及脂质过氧化物—丙二醛含量的变化关系，结果发现氯乙醇急性染毒组肝脏中上述的抗氧化酶活性于所设四个时点中均比对照组低（Ｐ＜０．０１及０．０５），而同时丙二醛含量高于对照组（Ｐ＜０．０１及０．０５），提示氯乙醇急性染毒大鼠中肝脏抗氧化酶活性受氯乙醇毒性所抑制，出现肝脏脂质过氧化并造成肝损害。同时，本文也发现氯乙醇急性染毒大鼠血清中丙二醛含量与肝脏丙二醛含量存在着高度密切的正相关关系（Ｐ＜０．０１），且血清中丙二醛含量比谷丙转氨酶活性早升高。
After single i.p. administration of chloroethanol (30mg/kgb.w.) the blood and live were collected at 3,6,12,24hours respectively.The activity of superoxide dismutase (SOD)、glutathione peroxidase (GSH Px) and the level of malondialdehyde (MDA) were investigated in liver homogenate of rats exposed to chloroethanol after the treatment.Moreever,the level of malondialdehyde (MDA) in Serum of the rats also was investigated.The results showed the activity of SOD and GSH Px in liver of rats acutely exposed to chloroethanol was significantly lower than that of the control (P<0.01,P<0.05),and the level of MDA in the former was higher (P<0.01,P<0.05) than that of latter when treated with chloroethanol.It is suggested that chloroethanol inhibited the activity of SOD and GSH Px,and induced lipid peroxidation in the liver of rats.Additionally,the MDA level of serum in rats exposed to chloroethanol was positively correlated with that of liver of those (P<0.01).It is a valuable indices detecting for damage caused by chloroethanol.
出处
《中国实验动物学杂志》
1998年第3期135-138,共4页
Chinese Journal of Laboratory Animal Science
