小鼠嗜肺巴氏杆菌病诊断及带菌状况调查

The Diagnosis and Investigate of Pasteurellosis in Mice

本文对一起罕见的清洁级昆明小鼠群中散发的嗜肺巴氏杆菌病进行了临床病理观察和病原学诊断，并对该动物群进行了带菌状况调查。该鼠群中嗜肺巴氏杆菌病发病率为３．８％，发病小鼠全部为三周龄左右，全身状况良好，仅表现出结膜炎，剖检除眼眶有米粒大脓肿外全身各脏器均未见异常；从脓肿中仅分离到嗜肺巴氏杆菌，本次流行株病原菌生物学特性显示部分菌株可有溶血性，吲哚试验阴性；其带菌率为：种鼠８０％、５～６周龄９０％，３～４周龄１００％。

It is reported that an rate infection with Pasteurella Pneumotropica in clean KM mice.The study included clinic and pathologic observation,pathogenic diagnosis and prevalence survey.It was observed that morbidity was 3.8% in the infected mice.The sick mice with the age about 3 weeks showed the normal general condition,but conjunction,little pus swelling in eye rim when autopsy was observed.Pasteurella pneumotropica was isolated from the pus swelling only and the biologic characteristic with hemolysis and Indol test (-) in some strains,was also found.The infection rate is different in each age group of the mice,which 80% in old age group,90% in 5-6 weeks and 100% in 3-4 weeks age group of the mouse.It is indicated that the young have higher sensitivity than the mature in the mice.