NOD小鼠糖尿病病症的初步观察

The Observation of the Diabetic Onset of NOD Mouse Strain

对１２６只ＮＯＤ小鼠自发性糖尿病发病情况观察，５２周后雌性发病率为５０％，雄性发病率为２８．３％。雌性发病早于雄性，发病期小鼠尿糖、血糖水平升高，发病后２～５周死亡。

mice of NOD inbred strain were observed for their diabetes from 3 to 52 weeks old.Total cumulative diabetes incidence in males was 28.3%,lower than that 50% in females Abrupt onset occurred among 10-33 weeks old,while male's onset was later than female's After 45 weeks old,few onset individuals could be found.The diabetic animals died within 2-5 weeks after the onset.Clinical features of the affected animals were glycosuria,hyperglycetemia,polydipsia,polyuria,polyphagia and body weight loss.Severe lymphocytic infiltration in the pancreatic islet was observed in prediabetic and diabetic animals.Insulin dependent diabetes mellitus (IDDM) of NOD mice was an autoimmune disease.NOD mice could be used as a model for human IDDM.