摘要
本文观察了经腹腔注射四氯化碳（每次４００ｍｇ／ｋｇｂ．ｗ，每周三次）亚急性染毒大鼠注药１、２、３周时肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶活力及脂质过氧化物—丙二醛含量的变化，结果发现四氯化碳亚急性染毒大鼠肝脏中上述的抗氧化酶活性在三个时间组均比对照组低（Ｐ＜０．０１），同时，丙二醛含量均高于对照组（Ｐ＜０．０１及０．０５），提示四氯化碳亚急性染毒大鼠肝脏抗氧化酶活性受四氯化碳毒性所抑制。
Both blood and liver were collected at 1,2,3 weeks after i.p.administration of carbon tetrachloride(400mg/kgb.w.),respectively.The activity of superoxide dismutase (SOD)、glutathione peroxidase (GSH-Px) and the level of malondialdehyde (MDA) were investigated in liver homogenate of rats.meanwhile,the level of malondialdehyde (MDA) in serum in the rats also was investigated.The result showed the activity of SOD and GSH-Px in liver of rats acutely exposed to carbon tetrachloride was significantly lower than that of the control (P<0.01) when treated with carbon tetrachloride lweek later,and the level of MDA in the former was higher than that of latter.It is suggested that carbon tetrachloride inhibited the activity of SOD and GSH-Px,and caused lipid peroxidation in the liver of rats.Additionally,No correlation was demonstrated between the MDA level of serum and liver in rats exposed to carbon tetrachloride (P>0.05).
出处
《中国实验动物学报》
CAS
CSCD
1998年第1期61-64,共4页
Acta Laboratorium Animalis Scientia Sinica
