L-精氨酸和/或维生素E对高脂膳家兔脂质过氧化损伤的保护作用

The Protective Effect of Arginine and/or Vitamine E on Lipoperoxidation in Experimental High-fat Diet Feeding Rabbits

目的：通过脂质过氧化物（LPO）、谷胱甘肽过氧化物酶（GSH－PX）、超氧化物歧化酶（SOD）以及一氧化氮合酶（NOS）M定探讨L－精氨酸（L－Arg）（35kg／kg）和／或维生素E（74mg／kg）对高脂膳诱发的新西兰纯种白兔实验性动脉粥样硬化形成的多脏器各生化指标（包括LPO、GSH－PX、SOD及NOS活性）的影响。方法：成年新西兰家兔随机分为正常对照组：（基础饲料加普通饮水）高脂对照组：（高脂饲料加普通饮水）L－Ars组：（高脂饲料加含有L－Ars35kg／kg饮水）L－Arg＋VE组（高脂饲料加含有L－Arg35kg／kg再加VE74mg／kg饮水）VE组（高脂饲料加含有VE74mg／kg饮水）观察12周。结果：L－精氨酸和／或维生素E能有效地抑制脂质过氧化损伤增强SOD、NOS和GSH－PX活性，提高机体抗氧化能力及减轻动脉粥样硬化形成的作用。结论：这些变化可能在动脉粥样硬化的发生发展中起重要作用。

Objective: Biochmical alterations of tissue were examined in experimental New Zealand whiterabbits. Methods: High-fat diet feeding. After killing the animals, we measured the lipid peroxides(LPO)、glutathione peroxidase (GSH-Px)、nitric oxide synthase (NOS) and superoxidedismutase (SOD) activities in heart, brain and liver. Results: the results demonstrated thatlipoperoxidation could be inhibited efficiently by L-Arg and/or VE and thus the process ofatherosclerosis was slowed down conclusion: These findings suggested that obviously function oftissus antioxidant systen in atherosclerosis rabbits has changed and these changes might play animportant role in the development of atherosclerosis.