缺氧感受和信号转导

Sensing and signaling of hypoxia

缺氧作为一种伤害刺激能够导致机体整体直至细胞水平发生相应的反应。对于外界氧分压的变化,氧感受器能够感受细胞内外氧分压的变化,产生活性氧(ROS),再由ROS激活下游激酶,直至缺氧相关转录因子的激活,产生诸如红细胞生成素(EPO)、血管衍生生长因子(VEGF)等,而使机体更好地适应外界变化。

As harmful stimulation, hypoxia can lead to the relevant response from the whole body level to the cell level. The oxygen sensor can sense the oxygen pressure change outside the cell and impel the cell to produce ROS. ROS continue to excite the junior kinase and the transcription factor relevant to hypoxia at last, with the cell producing the following substance such as EPO, VEGF. The former serial reaction can make the body adapt to the change outside the cell better.