酸性成纤维细胞生长因子受体及信号转导的研究进展

The development of the acid fibroblast growth factor's receptors and their signaling pathways

酸性成纤维细胞生长因子(aFGF)的生物学功能与受体结合、细胞信号转导具有密切的关系。近年来已发现5种成纤维细胞生长因子受体(FGFR),其中主要是FGFR-1、FGFR-2与aFGF结合并被激活,启动多条信号转导途径,引起胚胎发育、血管生成以及创伤修复等多种生物效应,其中,FGFR与aFGF结合后启动的MAPK途径是调节各种细胞趋化应答、分化、分裂的重要途径,是细胞增殖、分化等信息传递途径的交集点和共同通路。

The acid fibroblast growth factor's function have intimacy relationship with it's FGFR binding and it's signaling transduction. In the recent years the study of the FGFRs are developed and the detail mechanisms of these pharmacological effects of aFGF are received more attention. Today, we have detected five FGFR, the FGFR-1 and FGFR-2 are the main and important FGFR which were activated to start many signal transduction pathways. These ways advanced to impact embryogenesis、 angiogenesis and repair in trauma. We also realized that the MAPK pathway was the joint and common pathway which adjusted various kinds of cells chemotactic response, differentiation, mitosis.