氯氮平对首发精神分裂症偏执型患者血浆及脑脊液中白细胞介素2的影响

Study on the alterations of IL-2 in the plasma and cerebrospinal fluid of paranoid schizophrenia treated with clozapine

目的 研究氯氮平治疗前后精神分裂症偏执型患者血浆及脑脊液中IL 2的变化。方法 随机选取 30例住院患者为研究组 (单用氯氮平治疗 ) ,2 0名健康志愿者作为对照组。研究组均符合CCMD 3精神分裂症偏执型诊断标准。入组前后 ,采用酶联免疫吸附法测定两组血浆及脑脊液中IL 2的浓度 ,并进行比较。结果 治疗前研究组血浆及脑脊液IL 2水平显著高于对照组 ,两组有显著性差异 (P <0 .0 5 )。研究组治疗 6w末 ,且精神症状缓解后 ,血浆及脑脊液IL 2水平较治疗前明显降低 ,差异有极显著性 (P <0 .0 1) ;与对照组比较无显著性差异 (P >0 .0 5 )。结论 首发精神分裂症偏执型患者存在免疫功能紊乱。提示 ,血浆及脑脊液IL 2水平可以作为抗精神病药物 (尤其是氯氮平 )影响免疫学变化的一个敏感指标。

Objective To evaluate the alterations of interleukin-2(IL-2) in the plasma and cerebrospinal fluid of paranoid schizophrenia. Methods 30 in-patients who fulfilled CCMD-3 criteria for paranoid schizophrenia were enrolled as case group and 20 healthy volunteers were enrolled as control group.. We obtainend plasma when schizophrenic patients were both on admission and in a state of initial remission 6 weeks after admission. The contents of IL-2 were measured with emzyme-linked immunosorbent assay (ELISA). The paramters were performed by statistics analysis. Results On admission, the levels of IL-2 in the plasma and cerebrospinal fluid were significantly higher in schizophrenic patients in comparison to control group ( P<0.05 ) .Six weeks after admission, no pronounced difference was observed for the levels of IL-2 in the plasma (P >0.05).When initial remission compared with acute disease, the levels of IL-2 in the plasma were significantly lower (P<0.01).Conclusion Schizophrenic patients had immune dysfunction.