儿童抽动障碍ASO、IL-6和IL-8水平的研究

T-cell Subpopulations, ASO, IL-6 and IL-8 in Children with Tic Disorder

目的 :观察儿童抽动障碍患者抗链球菌溶血素O、T淋巴细胞亚群、血清IL -6、IL -8水平的变化 ,以探讨其发病可能机理。方法 :对 5 2例儿童抽动障碍患者和 3 0例正常儿童分别采用间接免疫SAP花环法检测T淋巴细胞亚群和ELISA法检测血清IL -6和IL -8水平。结果 :儿童抽动障碍患儿 ,T淋巴细胞亚群与对照组比较无统计学差异 ,抗链球菌溶血素O明显高于对照组 ,血清IL -6水平、IL -8水平两组无统计学差异。结论 :儿童抽动障碍患者可能存在免疫学方面的改变 ,其和免疫学的关系还有待进一步深入探讨。

Objective: To observe the changes of blood T-cell subpopulations, ASO,IL-6 and IL-8 in children with Tic disorder and explore the pathogenesis. Methods: T-cell subpopulations and concentration of IL-6, IL-8, ASO were measured in 52 children with tic disorder and 30 normal children using SAP and ELISA.Results:The numbers of CD3+、CD4+ and CD8+ cells had no significant difference between 32 children with tic disorder and 30 normal children, and the concentration of ASO in serum of children with tic disorder was markedly higher than those in normal children. The concentrations of IL-6 and IL-8 in serum had no significant difference between the two groups.Conclusion: There may be dysfunction in humoral immunity in tic disorder.