用集中注意法对抑郁症患者进行押韵汉字的分听研究

The Dichotic Listening Research for Different Chinese Rhyming Words in Patients with Major Depressive Disorder by Focused Attention

目的 :探讨抑郁症患者大脑半球机能不对称的特点。方法 :用集中注意法及两种押韵词 ,对5 8名健康被试、 115名抑郁症患者进行耳优势测试。结果 :1 健康组真词测听未见耳优势 ,而假词测听呈右耳 (左半球 )优势。 2 抑郁症患者真词测听未见耳优势 ,而假词测听呈增强的右耳 (左半球 )优势。 3 真词测听 ,共病焦虑障碍组无耳优势 ,非共病组有增强的右耳 (左半球 )优势 ;假词测听 ,两组均表现为右耳 (左半球 )优势 ,非共病组强于共病组。 4 HAMD、HAMA、SCL -90评分与真、假词偏侧指数无相关性。结论 :1 健康中国人对真词的加工与认知无耳优势 ,表明健康中国人在加工真词时需要左右两侧半球的协同参与 ;对假词的加工与认知则表现出右耳 (左半球 )优势 ,表明更为纯粹的言语材料的加工以左半球为主。 2 抑郁症患者对汉字词的加工与认知 ,表现出较健康人强的右耳 (左半球 )优势。 3 共病和非共病焦虑障碍者对汉字词的加工与认知 ,表现出较健康人强的右耳 (左半球 )优势 ,而非共病者较共病者右耳(左半球 )优势强。 4 患者的言语偏侧化指数与症状严重程度无相关性。 5 假词为较为理想的分听材料。

Objective:To explore the brain function asymmetry characters of the patients with major depressive disorder (MDD).Methods:The study examined the ear advantage of 58 healthy subjects, 115 patients with MDD using two kinds of rhyming words by the method of focused attention. Results:1.In healthy group, no ear advantage was found in true words test, but appeared significant right ear (left-hemisphere) advantage in pseudo-words test. 2.In MDD group, there was also no ear advantage in true words test, but appeared enhanced right ear (left-hemisphere) advantage in pseudo-words test. There was a significant difference between the MDD and healthy subjects. Among patient group, 3. by true words test, no ear advantage was found in those with a comorbid anxiety disorder, but those without comorbid anxiety appeared right ear advantage. By pseudo-word test, both patients with or without comorbid anxiety appeared right ear (left-hemisphere) advantage, and those without had larger advantage. there was a significant difference between this two groups. 4.HAMD, HAMA and SCL-90 ratings had no relation to asymmetry scores of true words or that of pseudo-words.Conclusions:1. both healthy control and MDD patients have no ear advantage for process and cognition of true words in, but as for that of pseudo-words, both of them appear right ear (left-hemisphere) advantage, with the MDD patients have greater advantage. 2.The patients with or without a comorbid anxiety disorder were different in response, patients with comorbid anxiety appear more close to normal control. 4. Asymmetry scores don’t correlate significantly with the scores of HAMD, HAMA or SCL-90. 5.The pseudo-words is the better choice as stimuli for dichotic listening test.